Vol. 12, no.1, 2020
РусскийEnglish
NANOSYSTEMS
Detection of carcinogenic and anticancerogenic properties of chemicals by means of the positron annihilation lifetime spectroscopy
Vsevolod M. Byakov, Sergey V. Stepanov
National Research Centre "Kurchatov Institute" - ITEP, http://www.itep.ru/
Moscow 117218, Russian Federation
E-mail: byakov@itep.ru, stepanov@itep.ru
Received February 14, 2020; peer reviewed February 21, 2020; accepted February 25, 2020
Abstract. It is a well known fact that the major cause of a human cancer are chemical carcinogens. Most of them are strong electrophiles. Variation of the Ps formation probability vs. concentration of a testing substance in a solvent (modeling intracellular milieu) may serve as an indicator of carcinogenic properties of the solute. Being an effective scavenger of track electrons, chemical carcinogens strongly inhibit Ps formation. Efficiency of this inhibition may successfully serve as a measure of their carcinogenic and anticarcinogenic properties. It is demonstrated that carcinogenic activity of macro samples is determined by their values of work function.
Keywords: carcinogens, anticarcinogens, positron, annihilation, positronium
UDC 539.124.6+541.6
RENSIT, 2020, 12(1):115-128. DOI: 10.17725/rensit.2020.12.115.
Full-text electronic version of this article - web site http://en.rensit.ru/vypuski/article/312/12(1)115-128e.pdf