Vol. 11, no.3, 2019
РусскийEnglish
MEDICAL PHYSICS
NEW ADDITIVE TECHNOLOGIES FOR FORMING COMPLEX BONE STRUCTURES FOR MEDICAL AND BIOLOGICAL APPLICATIONS
Vladimir N. Gorshenev
Emanuel Institute of Biochemical Physics of RAS, http://ibcp.chph.ras.ru/
Moscow 119334, Russian Federation
E-mail: gor@sky.chph.ras.ru
Vladimir V. Kolesov
Kotelnikov Institute of Radioengineering and Electronics of RAS, http://cplire.ru/
Moscow 125009, Russian Federation
E-mail: kvv@cplire.ru
Mayya Yu. Ziangirova, Larisa M. Krasnopolskaya
Gause Institute of New Antibiotics, http://www.gause-inst.ru/
Moscow 119021, Russian Federation
E-mail: pchelka_mayya@mail.ru, lmkrasnopolska@gmail.com
Alexander A. Prosvirin
Yevdokimov Moscow State University of Medicine and Dentistry, http://www.msmsu.ru
Moscow 127473, Russian Federation
E-mail: prosvirin@mail.ru
Andrei T. Teleshev
Moscow Pedagogical State University, http://mpgu.su
Moscow 119001, Russian Federation
E-mail: teleshev@mail.ru
Received 30.09.2019, peer reviewed 14.10.2019, accepted 21.10.2019
Abstract. A synthesis of nanosized hydroxyapatite by the exchange reaction between diammonium phosphate and calcium nitrate under conditions of mechano-acoustic processing of the reaction mixture was developed. Methods are proposed for purifying hydroxyapatite from by-products. By dispersing raw materials of animal origin, a protein hydrosol was obtained in the medium of which hydroxyapatite was synthesized and a collagen-calcium-phosphate composite was obtained. Methods for the formation of porous collagen-calcium-phosphate composites, among which the effect of microwave radiation, are considered. It is shown that based on the developed biocompositions: calcium phosphate pastes, compositions from thermoplastic biodegradable polymers, non-woven fibrous materials, fabric-engineering constructions with an adjustable architecture can be made to solve various biomedical problems. The creation of three-dimensional structures capable of performing the functions of a particular natural tissue of the body, based on a combination of cells and scaffolds (three-dimensional structures, matrix, scaffold), as well as other factors affecting cell growth, their differentiation and organization of the extracellular matrix, is an important task of the tissue engineering.
Keywords: nanoscale hydroxyapatite, porous collagen-calcium-phosphate compounds, biodegradable polymers, non-woven fibrous materials, tissue engineering structures, 3D technologies
UDC 615.46
RENSIT, 2019, 11(2):369-390 DOI: 10.17725/rensit.2019.11.369
Full-text electronic version of this article - web site http://en.rensit.ru/vypuski/article/297/11(3)369-390e.pdf